[3] Panzinger's office consisted of the following subdivisions: From 4 September 1943 to 6 May 1944 Panzinger succeeded Humbert Achamer-Pifrader as the commander of the three sub-group Einsatzkommando of Einsatzgruppen A (mobile killing squads), which oversaw the Security Police matters in the area of Army Group North in the Baltic states and Belorussia.

A reorganization of Amt IV of the Reich Security Main Office (RSHA) in March 1944 led to a breakdown of territory divisions between Panzinger and Achamer-Pifrader.

Shortly thereafter, Panzinger was appointed Chief of RSHA Amt V, the Kriminalpolizei (Kripo; Criminal Police), also known as the Reichskriminalpolizeiamt (RKPA).

[4] He succeeded Arthur Nebe, who was denounced and executed subsequent to the failed July assassination attempt on Hitler.

Panzinger was responsible for the murder of prisoner of war French general Gustave Marie Maurice Mesny on 19 January 1945 near the village of Nossen.

That same year, after charges were brought against him for the murder of Maurice Mesny, Panzinger committed suicide by poisoning himself in his cell on 8 August 1959.