In 1917, he became active in the municipality politics and in 1922 he became a member of the Skaraborgs läns hushållningssällskaps förvaltningsutskott.

In 1933 he became a member of the special committee for crisis politics, he participated in the investigations by the Riksdag in 1938 for farming.

As a leader he mentioned the "Jew-problem" and supported a restrictive Swedish refugee policy.

[4] In 1939, the Hansson III Cabinet was formed, and Domö was appointed to the position of Minister of Commerce and Industry.

[3] After professor Gösta Bagge had announced that he intended to resign as the leader of the Moderate Party Domö became the strongest candidate to replace him.