Construction of the airfield began in September 1935, although the Treaty of Versailles prohibited Germany to have an air force.

[1] It was equipped with Heinkel He 111 P. With the start of World War II, the KG 54 left Fritzlar in September 1939.

The group was equipped with Messerschmitt Bf 110 G and Junkers Ju 88 G.[1] In March 1945, a training squadron of Nachtjagdgeschwader 101 (NJG 101) was based in Fritzlar.

The lack of fuel made the school unable to train new pilots, and so the aviation trainers were assigned for combat duty.

[1] The barely damaged Luftwaffe airfield was captured by parts of the 9th Infantry Division of the US Army on 30 March 1945.

[1] On 12/13 April 1945, parts of the 404th Fighter Group and 365th Fighter Group Hellcats of the United States Army Air Forces (USAAF) moved to Fritzlar and supported ground troops with their P-47 Thunderbolts until they reached the Elbe river.

[1] During the Berlin Blockade in 1948/49, Fritzlar Air Base served as radio beacon and emergency airfield on route back to Frankfurt and Wiesbaden.