The film starts with the ending of From Vegas to Macau II, where cardshark Ken's lifelong lover-nemesis, Molly, skydives without a parachute from her private jet.

She now appears to be trapped inside some sort of laser bubble — unconscious, naked and horribly airbrushed — while her admirer, mad scientist JC, fumes about making Ken pay within his lair underneath Paradise Island, off the coast of Thailand.

An explosion during the wedding causes both Rainbow and Vincent to each fall into a coma, while Ken and Mark are accused to have taken DOA's[clarification needed] illicit money.

Ken and Mark end up in prison, a convenient venue for them to play a card game using cigarettes as chips (so technically, it is not gambling), but are then abruptly rescued from a criminal raid and take refuge in Michael's home in Singapore.

Michael's place serves as a cost-effective location for a lengthy stretch, while a gaggle of characters drop in and out to deliver gags.

and credited the film to "Single-handedly killing a once internationally beloved, one-of-a-kind Hong Kong genre that Wong himself invented", noting that Wong Jing and Andrew Lau had "mangled their material to suit mainland criteria that they’re left with a string of moronic gags barely held together by cheapskate production values.