It has served as a hotel, private home, a fine dining restaurant, museum, and a fast food establishment (McDonald's).

[2] The Frontier House, built in 1824, is situated at 460 Center Street, Lewiston, New York, of Niagara County and was hailed as the best hotel west of Albany.

Prominent business men of Lewiston, Benjamin and Samuel Barton along with Joshua Fairbanks headed the building of the tavern.

[3] The Frontier House was constructed of stone from the Bay of Quinte at the Northeastern end of Lake Ontario.

Its rectangular shape, double parallel chimneys, oval windows, full-width porch and hipped roof is characterized as the Federal style of architecture.

Dewitt Clinton, President William McKinley, Samuel Clemens, Charles Dickens, Henry Clay, Daniel Webster, John L. Sullivan and Jenny Lind were all honored guests of the Frontier House.

In the 1800s ten coach trains arrived and departed from the Frontier House hotel daily carrying these among other influential people.

The ghost of an elderly man was purportedly seen in the pantry and an employee showering in the residence alleges to have seen the silhouette of a woman.