Furan-2-ylmethanethiol

Furan-2-ylmethanethiol (2-furanmethanethiol) is an organic compound containing a furan substituted with a sulfanylmethyl group.

It is a clear colourless liquid when pure, but it becomes yellow coloured upon prolonged standing.

It possesses a strong odour of roasted coffee and a bitter taste.

It has been identified as a trigger molecule for parosmia following COVID-19 infection.

[1][2] Furan-2-ylmethanethiol is easily prepared by reacting furfuryl alcohol with thiourea in hydrochloric acid via an intermediate isothiouronium salt which is hydrolized to the thiol by heating with sodium hydroxide.

Kekulé, skeletal formula of furan-2-ylmethanethiol
Kekulé, skeletal formula of furan-2-ylmethanethiol
Ball-and-stick model
Ball-and-stick model
Synthesis of furfuryl mercaptane (Furan-2-ylmethanethiol)
Synthesis of furfuryl mercaptane (Furan-2-ylmethanethiol)