The cutscenes of the game are presented as an entire "lost episode" of Futurama on the DVD of The Beast with a Billion Backs.

The game begins with Professor Farnsworth, wearing a sombrero, selling the Planet Express delivery company to Mom, explaining that it had been losing money for years due to mismanagement.

After Fry is crushed to death under a pile of debris, he is resurrected by the Professor's new invention, the Re-animator (which closely resembles a giant toaster), which brings the crew back to life every time they die.

After discovering that the ship's dark matter engine is beyond repair, and informing the crew that the back-up was pawned in exchange for a gun, the Professor sends Fry off to retrieve it, having to travel via the sewers to avoid curfew.

After Leela destroys the Sun Temple, the crew then head for the planet of Bogad, where Farnsworth's mentor, Adoy, lives.

Fry, Leela and Bender manage to travel back to a few minutes before Mom buys Planet Express from the Professor.

Matt Groening served as Executive game developer and David X. Cohen directed the voice actors.

Cast members Phil LaMarr and Lauren Tom weren't included in the game due to budgetary reasons.

[12] The Lost Adventure compilation also removes meta references to being a video game and adds new effects to the sound mix.

[28] Tim Tracy of an American video game and entertainment media website GameSpot gave 4.9/10 (Poor).

Though praised voice-acting, cutscenes, Cel-shaded visual, writing and plot overall, criticized was camera and targeting (aiming) system.