[4][5][6] On 6 December 1523, Pedro led his brothers, cousins, and uncle, including Gómez, out of Tenochtitlan in command of a Spanish army consisting of 120 horsemen with 170 horses, 300 foot soldiers, and 130 crossbowmen to what is modern-day Guatemala, beginning the Spanish conquest of Guatemala that would last well into the 17th century.

[6][7][8] Pedro was known for his cruelness and ruthlessness during his conquest of Guatemala, and the same attributes were shared by his brothers, including Gómez.

Atrocities, such as massacres, looting, village burning, rapes, and kidnapping indigenous people for slave labor, were commonly committed by their men.

[8][9] By the end of 1524, Pedro, Jorge, and Gómez began the conquest of Cuzcatlan in modern-day El Salvador.

[4][6][10] In the Battle of Tacuzcalco, Alvarado commanded twenty cavalrymen against the left flank of the indigenous army under Atlácatl.

[4][6] Alvarado commanded 90 cavalrymen in the Spanish victory at the Battle of Reinogüelén against Mapuche forces under Michimalonco in September 1536.

[4][20][21] The city was abandoned and refounded in 1541 and later received the title of "Very Noble and Very Loyal" by the Spanish Emperor Carlos I in 1543.

[4] Pizarro was assassinated on 26 June 1541 on orders of Diego de Almagro II in revenge for executing his father in 1538.