[1] Construction of the present palace in Renaissance style was initiated in 1558 by Ulrich, Duke of Mecklenburg, in place of a medieval castle.

In 1657, Gustav Adolf, the last Duke of Güstrow, engaged Charles Philippe Dieussart to refurbish parts of his palace in modern style.

The banquet hall's ceiling has unique stucco paintings of hunting scenes which are adaptations from Dutch copper engravings.

The refurbished former dining halls, residential and reception rooms have exhibits of paintings of Cranach, Marten de Vos, and Tintoretto.

[2] The palace houses a museum related to the male line of Duchess Elisabeth Sophie of Mecklenburg's family, [3] presenting also art exhibitions and concerts.