The film stars Zach Galifianakis, Bill Nighy, and Will Arnett and it features the voices of Sam Rockwell, Tracy Morgan, Penélope Cruz, Jon Favreau, Nicolas Cage, and Steve Buscemi.

[2] The story follows Darwin (a guinea pig) and his team of specially trained rodents who, after failing a mission, must break out of a pet shop and stop an evil billionaire from taking over the world.

A special government program, training and deploying highly intelligent rodents as secret agents, is facing abolition from the FBI.

Darwin finds a classified file titled Clusterstorm on Saber's personal computer, containing plans for global extermination, and downloads it to his PDA.

However, the next day during a briefing with the FBI, the file turns out to be false, which angers Ben's superior, Agent Kip Killian, who shuts down the program.

Blaster and Juarez get themselves sold to a family, while Speckles pretends to be dead to get buried, but is thrown into a garbage truck instead, seemingly crushed to death.

While Blaster and Juarez escape their new owners, Ben and his assistant, Marcie retrieve Darwin's PDA from the FBI, and discover that it is infected with an extermination virus.

Saber holds a meeting with his associates, including his prime engineer, the mysterious "Mr. Yanshu", and reports that Clusterstorm will launch in less than 48 hours.

Deciding to use the infected PDA to shut down the microchips, they go to Saber's mansion in their hamster ball-shaped vehicles, during which they escape from the FBI agents sent by Killian to capture them.

At Saber's mansion, the team tries to reach the mainframe, but Hurley accidentally steps on a bomb-trap, resulting in an explosion which separates Blaster and Juarez from Darwin.

When an FBI field team led by Killian arrives at Saber's mansion to arrest him, he claims that he simply wanted to use the microchips for electronic communication.

He elaborates his plan to use the Saberling products for a bombardment of space debris to make Earth's surface uninhabitable, therefore destroying humanity as revenge for killing his family.

G-Force receives personal recognition from the FBI Director, who tells them that Saber had been assigned to recall all his products, while Speckles is given the duty of removing the microchips before rejoining the team.

On 17 October, it was announced that Sam Rockwell, Tracy Morgan, Penélope Cruz, Nicolas Cage, Jon Favreau, Steve Buscemi, Zach Galifianakis, Bill Nighy, Kelli Garner, Will Arnett, Gabriel Casseus and Jack Conley joined the film.