This was a major reason for his support for the Pakistan Movement which he used as a tool for his purposes, even though the Muslim League leader Muhammad Ali Jinnah wanted everyone to be given rights regardless of their religion, and Islamic teachings also emphasize the same.

After the partition of India, when many people from both sides were persecuted, the bilateral land exchange between the refugee Hindu Sindhis from Sindh and Muslim Muhajirs from the parts of India started, which created the governance and influence of Muhajirs over the land, which the Sindhi Vadera Class wanted to occupy.

[10] Syed was one of the earliest Sindhi politician who sought the creation of Islamic Pakistan, and became a vocal supporter of the Two-Nation Theory, advocated by the Muslim League leader Muhammad Ali Jinnah; Syed's political propaganda for a purely 'Muslim-dominated state' is witnessed after the Manzilgah incident, where he wanted to cleanse Sindh of its Hindus, stating: "all Hindus shall be driven out of Sindh like the Jews from Germany".

[12][2] He restated his political propaganda of ideologies which advocated for Islamic principles, secularism, Sindhi nationalism and laid the basis for Sindhudesh Movement.

[19][18][20] Two days after this conference, his native town Sann observed a shutter-down strike in protest against the injustices of the Allied Powers against the Ottoman Caliphate on 20 March 1920.

[21][22] Syed visited the office of the Collector in Karachi on 23 June 1921 to free his lands from the custody of Court of Wards but he was refused.

Like Ibrahim Joyo, Syed blended Sindhi nationalism with Communism and Sufism through the ideas of Gandhi and Marx.

Syed Sindhi's position brought him ample opportunity to have free income through tributes, cash offerings and landed property.

[24] In the early 1920s, Syed opened Anglo-Vernacular (AV) school in his village Sann, where education for certain language classes was free of cost.

He is also the author of more than 60 books, (with) subjects ranging from politics, religion, culture, literature and commentaries on famous poet Shah Abdul Latif Bhitai.