[5][1] Madhavan Nair is a leading technologist in the field of rocket systems and has made significant contribution to the development of multi-stage satellite launch vehicles, achieving self-reliance in independent access to space using indigenous technologies.

Nair and his team have advanced their work in the face of several challenges in the regime of technology denials by adopting several innovations and novel techniques to realise world class launch vehicle systems.

Further, as Director of the Liquid Propulsion Systems Centre of ISRO, he played a central role in the design and development of the crucial cryogenic engine for GSLV.

Major thrust are in scientific exploration of outer space using the Astrosat and Chandrayaan (Moon) missions apart from implementing schemes for telemedicine, tele-education and disaster management support systems.

He is also providing guidance and leadership in undertaking new technology developments related to launch vehicle, spacecraft for communication, remote sensing and applications programmes to meet societal needs.

[citation needed] G. Madhavan Nair initiated and implemented the establishment of Indian Institute of Space Science and Technology in Thiruvananthapuram.

[citation needed] The contract signed between Antrix Corporation and Devas Multimedia Private Limited on 28 January 2005 during Nair's tenure as chairman of ISRO and secretary of Department of Space, was controversial.

[8] Nair has promoted space science and technology for the socio-economic benefit of India, he is also the chairman of the Governing Body of the Antrix Corporation, Bangalore.