The Guangzhou–Macau Expressway (Chinese: 广州－澳门高速公路), designated as G0425 and commonly referred to as the Guang'ao Expressway (Chinese: 广澳高速公路), is an expressway that connects the cities of Guangzhou, Guangdong, and Macau, a Special Administrative Region of the People's Republic of China.

It is a spur line of the G4 Beijing–Hong Kong and Macau Expressway.

The extension to Macau at the Lotus Bridge is planned, so the current southern terminus is in Zhuhai at Zhuhai Avenue.

The major cities connected by this expressway are: Note: italic indicates the routes that were available in 2013 network plan, but removed in 2022 network plan