The Jishuang Expressway passes through Shuangliao, Siping, Liaoyuan, and Tonghua, before finally ending in Ji'an.

The expressway's southeastern terminus, the town of Taiwang [zh] in Ji'an,[1] is connected to the North Korean city of Manpo through the Ji'an Yalu River Border Road Bridge (Chinese: 集安至满浦界河公路大桥), which crosses the Yalu River.

[1] This bridge, the subject of international attention, was completed in 2016, but was only opened to traffic on April 8, 2019.

[2] North Korea has plans to extend the Pyongyang-Huichon Expressway to the border at Manpo.

[1] On September 28, 2020, the section of the expressway linking the northwestern terminus of Shuangliao to Dongfeng County in Liaoyuan was completed.