The north terminus of G4211 is at Tianbao Bridge in Yuhuatai District, Nanjing, and the south terminus connects to G50 and G5011 Wuhu-Hefei Expressway via a cloverleaf interchange in Wuhu.

The route crosses Jiangsu-Anhui border at an exit to G205 and enters Ma'anshan, Anhui.

G4211 continues to run parallel to G205, but bypasses downtown Ma'anshan to its east.

At Nanhuanlu Road exit, the two parallel routes are connected via a G205 spur.

It proceeds southbound until eventually terminating at a cloverleaf interchange with G50 and G5011 west to downtown Wuhu.