GLACIER (General Laboratory Active Cryogenic ISS Experiment Refrigerator) was designed and developed by University of Alabama at Birmingham (UAB) Center for Biophysical Sciences and Engineering (CBSE) for NASA Cold Stowage.
Glacier was originally designed for use on board the Space Shuttle, but is now used for storing scientific samples on ISS in the EXpedite the PRocessing of Experiments to Space Station (EXPRESS) rack, and transporting samples to/from orbit via the SpaceX Dragon or Cygnus spacecraft.
GLACIER is a double middeck locker equivalent payload designed to provide thermal control between +4 °C and -160 °C.
[1] In 2002 NASA began development of several spaceflight cold stowage systems to work in conjunction with the large (ISS Rack sized) ESA MELFI and Cryosystem freezers.
The combination of these goals presented several significant technical challenges, and prompted NASA to implement a two-phase development approach.