[5][6][7][8] The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules.

Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression.

Alternatively spliced transcript variants encoding different isoforms have been identified.

[5] Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.

[9] GRB10 has been shown to interact with This article incorporates text from the United States National Library of Medicine, which is in the public domain.