[6] In 2014, with a $200 million investment from Cohen, Plotkin founded Melvin Capital Management, a New York-based hedge fund which he named after his grandfather.

[9] Despite receiving $2 billion from Kenneth C. Griffin and $750 million from Steve Cohen, on May 18, 2021, Bloomberg announced Melvin Capital went defunct shorting GameStop and Gabe Plotkin would be shutting down his firm.

[13] In June 2023, Plotkin along with Rick Schnall purchased the Charlotte Hornets from majority owner Michael Jordan,[14] who will continue to hold a minority interest.

[8] He is on the board of advisors to Children of Fallen Patriots Foundation, an organization which provides scholarships and mentorship to individuals who lost a parent in the line of duty.

[11] Through the Gabriel and Yaara Plotkin Family Foundation, he and his wife have supported organizations like the Wounded Warrior Project and Chabad of Southampton.