It quotes the biblical account of the Annunciation (Luke, Chapter 1, verses 26–38) and Mary's Magnificat (Luke 1.46–55) with the opening lines:[1] The angel Gabriel from heaven came, his wings as drifted snow, his eyes as flame; "All hail", said he, "thou lowly maiden Mary, most highly favoured lady."

The use of the lilting phrase "Most highly favoured lady" made it the favourite carol of Richard Harries, Bishop of Oxford.

[4] Notable modern interpretations include a track on Sting's single "Russians" (1985) and on his album If on a Winter's Night... (2009).

[5] English rock band Marillion recorded a version for their 1999 fan club-exclusive album Christmas.Marillion, which was also performed on their 2003 DVD Christmas in the Chapel.

Amanda Palmer is featured on Amazon's Exclusive Holiday Playlist "All Is Bright" singing the song a cappella, accompanied by a choir.