Grupello was born as the son of Bernardo Rupelli, an Italian cavalry captain in Spanish service, and his Flemish wife Cornelia Delinck.

[3] From 1650 onwards, Quellinus worked for fifteen years on the new city hall in Amsterdam together with the lead architect Jacob van Campen.

Now called the Royal Palace on the Dam, this construction project, and in particular the marble decorations that Quellinus and his workshop produced, became an example for other buildings in Amsterdam.

[3][5] He completed a further two years of study in Paris and Versailles, where he was in contact with his compatriots Philippe de Buyster, Gerard van Opstal and Martin Desjardins and learned the technique of bronze casting.

[2] Grupello collaborated from about 1673 to 1678 on the decorative project for the funerary chapel of Duke Lamoral of Thorn and Taxis (in the Our Blessed Lady of Zavel Church in Brussels).

In other words, the child could represent the son of the Duke of Lamoral who after the early death of his father had to continue the family name and business.

He created numerous sculptures of the royal couple in marble and bronze, and was responsible for the supervision of craftsmen who worked on the Elector's palaces.

Grupello continued to live in Düsseldorf and in 1619 the Holy Roman Emperor Charles VI appointed him as Imperial sculptor.

In 1725, Grupello and his wife moved into the quarters at Ehrenstein Castle in Kerkrade (now in the Netherlands) of their daughter, who was married to an imperial official.

He executed works in marble, ivory and wood and was rare among his contemporary Flemish Baroque sculptors in that he also made bronze statues.

[1] A major work that Grupello created in this style in Brussels is the marble wall fountain, intended for the main ballroom of the wholesale fishmongers guild.