Gabriel Mureșan was born on 13 February 1982 in Sighișoara, Romania, starting to play junior level football while being aged 13 at local club, Dealul Mare.

[1][2][3][4] In 2005 when Sabău left Mediaș to go at Gloria Bistrița he took Mureșan with him, giving him his Liga I debut on 24 September in a 2–1 away loss in front of Pandurii Târgu Jiu.

[1][9][14] He scored an important goal with a header in a 2–1 win against FK Sarajevo from the 2009–10 Europa League play-off which helped the team reach the group stage where he played four games, receiving a red card in a 3–2 loss in front of Sparta Prague.

[1][3][19] He made his Russian Premier League debut on 16 July 2013 when coach Anatoliy Davydov used him all the minutes in a 2–0 away loss in front of Amkar Perm.

[1][3][4][24] He started the following season by winning the Supercupa României, coach Dan Petrescu using him the full 90 minutes in the 1–0 victory against Steaua, then he played in ASA's 4–2 aggregate loss in front of Saint-Étienne from the third qualifying round of the Europa League, having a total of 28 appearances with one goal scored in European competitions.

[1][3][25] Gabriel Mureșan made his last Liga I appearance on 15 April 2017 in a 0–0 with Poli Timișoara, having a total of 260 matches with 37 goals scored in the competition.

[1][26] Gabriel Mureșan made nine appearance at international level for Romania, making his debut on 2 June 2007 when coach Victor Pițurcă used him as a substitute in order to replace Dorel Stoica in the 79th minute of a Euro 2008 qualification game against Slovenia which ended with a 2–1 victory.