[1] In 1525, the queen regent, Louise of Savoy sent Bishop Gramont to Spain to secure the freedom of Francis I.
[1] In 1526, he was imprisoned by Charles V, Holy Roman Emperor, who was angry at his role in founding the League of Cognac; when England and France arrested the imperial ambassadors, the emperor ordered Bishop Gramont released.
[1] Returning to the Kingdom of France, he was despatched to the Kingdom of England in an attempt to encourage Henry VIII of England to divorce Catherine of Aragon and form a French alliance by marrying Marguerite de Navarre, the sister of King Francis and the widow of Charles IV, Duke of Alençon.
[1] He received the red hat and the titular church of San Giovanni a Porta Latina on 22 June 1530.
[1] In 1533 he negotiated the marriage between Henry, Duke of Orléans and Catherine de' Medici, the niece of Pope Clement VII.