[2] Gadsden County is included in the Tallahassee Metropolitan Statistical Area.

[3] It was named for James Gadsden[4] of South Carolina, who served as Andrew Jackson's aide-de-camp in Florida in 1818.

Gadsden County is historically known for its tobacco crop which is obsolete today.

[5] Gadsden County is part of the Tallahassee Metropolitan Statistical Area.

Its western border with Jackson County forms the boundary in this area between the Eastern and Central Time Zones.

The 2020 United States census counted 43,826 people, 16,806 households, and 11,239 families in Gadsden County, Florida.

28.4% of households consisted of individuals and 13.3% had someone living alone who was 65 years of age or older.

[15] The 2016-2020 5-year American Community Survey estimates show that the median household income was $41,135 (with a margin of error of +/- $2,461).

23.90% of all households were made up of individuals, and 9.50% had someone living alone who was 65 years of age or older.

[30] No Democratic gubernatorial or presidential candidate has received less than 60% of the vote in the county since 1992.

In the 2022 gubernatorial election, it was one of only five counties in the state to vote for Democratic nominee Charlie Crist over incumbent Republican governor Ron DeSantis, and it was the only one to give Crist more than 60% of the vote.

According to the secretary of state's office, Democrats maintain a massive majority of registered voters in Gadsden County.

These two lines meet in Chatahoochee and served Amtrak's Sunset Limited until it was truncated to New Orleans in 2005 by Hurricane Katrina.

The line enters from Liberty County, then crosses SR 12 in Greensboro, runs under I-10, follows CR 268 in Hardaway, and then turns west into Chatahoochee.

Public Transportation is provided by Big Bend Transit, which operates 3 bus routes in the county.