[2] The hotel was leveled by fire and rebuilt in 1929 by architect from El Paso Henry Trost.

[2] A stained glass window mural of the Southwest Desert by 5th generation artisan Ralph Baker, who studied under Louis Comfort Tiffany, extends forty-two feet across one wall of the massive mezzanine.

The hotel's vaulted stained glass skylights run the full length of the lobby.

[5] The hotel is said to be haunted, especially in Room 333, and has been in "ghost" shows on television, such as an episode of Sightings in 1995.

[2][6][4][5] The Gadsden Hotel has also been in several movies, including The Life and Times of Judge Roy Bean with Paul Newman, Terminal Velocity with Charlie Sheen and Nastassja Kinski, and Ruby Jean and Joe with Tom Selleck.