The title is both a reference to the islands on which part of the story plays out, and a tribute to Charles Darwin, on whose theory Vonnegut relies to reach his own conclusions.

Over the next million years, their descendants, the only fertile humans left on the planet, eventually evolve into a furry species resembling sea lions: though possibly still able to walk upright (it is not explicitly mentioned, but it is stated that they occasionally catch land animals), they have a snout with teeth adapted for catching fish, a streamlined skull and flipper-like hands with rudimentary fingers (described as "nubbins").

The following authors are quoted (in order of their appearance in the book): Anne Frank, Alfred Tennyson, Rudyard Kipling, John Masefield, William Cullen Bryant, Ambrose Bierce, Lord Byron, Noble Claggett, John Greenleaf Whittier, Benjamin Franklin, John Heywood, Cesare Bonesana Beccaria, Bertolt Brecht, Saint John, Charles Dickens, Isaac Watts, William Shakespeare, Plato, Robert Browning, Jean de La Fontaine, François Rabelais, Patrick R. Chalmers, Michel de Montaigne, Joseph Conrad, George William Curtis, Samuel Butler, T. S. Eliot, A. E. Housman, Oscar Hammerstein II, Edgar Allan Poe, Charles E. Carryl, Samuel Johnson, Thomas Carlyle, Edward Lear, Henry David Thoreau, Sophocles, Robert Frost, and Charles Darwin.

In 2014, artists Tucker Marder and Christian Scheider adapted "Galapagos" into a live theatrical performance at the new Parrish Art Museum in Watermill, N.Y.

Endorsed by the Kurt Vonnegut Estate, the multi-media production featured 26 performers including Bob Balaban; live orchestral underscoring composed and conducted by Forrest Gray featuring Max Feldschuh on vibraphone and Ken Sacks on mbira; animal costumes by Isla Hansen; a three-story scenic design by Shelby Jackson; experimental video projections by James Bayard; and choreography by Matt Davies.