The Galería Pedro Esquerré occupies the building known as "La Vigía", built between 1880 and 1830[verification needed] on the land that was first destined for the Customs House and the Corregidor.

It received its name in homage to the plastic artist Pedro Esquerré from the province of Matanzas, painter of the work "The trial of Osiris", a mural appreciated by Che Guevara in 1960.

It appears as the venue for the Havana Biennial on several occasions and collaborated on the most international project to date in Matanzas: "Rios intermitentes" presented in 2019 by María Magdalena Campos-Pons with artists such as Carrie Mae Weems, Melvin Edwards, Paul Stephen Benjamin, Alicia Henry, and Jamaal B.

[3] After a forced close down during the Covid pandemic in 2020, the Gallery reopened in 2021 with the exhibition "Seguimos en combate", curated by Alexander Lobaina and featuring local artists like Erich González Triana, Alejandro Vega Baró, Adversi Alonso, Alexis Plasencia García, Adrián Socorro among others.

[4] In collaboration with The Ludwig Foundation of Cuba, the Center showed in May 2022 the exhibition Vest + Menté with works by Swiss-Cuban artist Daniel Garbade.