Polskikh became famous after playing lead roles in such Soviet films as Walking the Streets of Moscow (1962), The Journalist (1967) and Expectations (1966).

Her dream came true in 1960 when Galina managed to enter All-Union State Institute of Cinematography, the leading film school in the USSR and Russia.

Polskikh became famous after the lead role in The Wild Dingo Dog released in 1962 that dealt with teenager love.

The lead roles in Walking the Streets of Moscow (1962) and The Journalist (1967) directed by her teacher Sergei Gerasimov made Polskikh one of the most outstanding film stars in the Soviet Union.

The distinctive feature of Polskikh's acting was convincing depiction of subtle emotions of female personages in affecting scenes.