The Academy was originally based in the Convento degli Olivetani at Montemorcino, where it began to assemble a collection of paintings and drawings.

With the addition of acquisitions, donations and bequests, the pinacoteca became the Regia Galleria Vannucci in 1918, under the patronage of the king.

Over the years the entire complex of Palazzo dei Priori has been repeatedly affected by renovations and functional adaptation.

[1] Chronologically ordered, the permanent collection has Renaissance and Medieval paintings and sculptures from Italian artists such as Arnolfo di Cambio, Nicola Pisano, Giovanni Pisano, Duccio, Gentile da Fabriano, Fra Angelico, Benozzo Gozzoli, Giovanni Boccati and Piero della Francesca.

The particular attention of the collection is given to the Umbrian masters; Benedetto Bonfigli, Bartolomeo Caporali, Fiorenzo di Lorenzo, Perugino, Pintoricchio and their students and followers.