Gamble House is a historic farmhouse located near Nesmith, Williamsburg County, South Carolina.

It dates to the early-19th century, and is a small wooden dwelling set upon brick piers with a steeply pitched gable roof.

It consists of a central two-story core, with later additions of small one-story wings.

[2][3] It was listed in the National Register of Historic Places in 1978.

This article about a property in Williamsburg County, South Carolina on the National Register of Historic Places is a stub.