The CDP covers an expansive range that falls within the communities of Crofton, Waugh Chapel, and Odenton.

The original village of Gambrills was located on Annapolis Road, 2 miles (3 km) southeast of the center of Odenton.

[citation needed] It is the location of Whites Hall Farm, the birthplace and boyhood home of Maryland native Johns Hopkins.

Gambrills is located along Maryland Route 175 (Annapolis Road), and extends south and southeast around the town of Crofton.

[citation needed] Gambrills is the site of two large power centers adjacent to one another: Waugh Chapel Towne Centre (650,000 sq.