[1] The central characters are three childhood friends from Herne Bay in Kent: laddish agoraphobe Matthew Malone (Ben Chaplin in the first series and Neil Stuke in the second and third), man-eater Amanda "Mandy" Wilkins (Samantha Janus), and wimpish Martin Henson (Matthew Cottle).

In their twenties, the trio move into and share a flat in Battersea, south-west London, which Matthew bought with his inheritance, and the series follows their lives as flatmates.

Among other music included was "Dogs of Lust" by The The, "Nowhere" by Therapy?, "From Despair to Where" by Manic Street Preachers, "Girls & Boys" by Blur, "God!

Bernadette Davis voiced her desire to focus the next series on the development of Matthew, who due to his flat-bound existence, she began to find increasingly hard to write for; the addition of a "radicalist" new gay or lesbian housemate was also part of her suggestions to add a new element of interest to the series.

[5] Game On was nominated for Best Comedy (Programme or Series) at the 1997 BAFTAs,[6] along with Absolutely Fabulous and Father Ted; the category was won by Only Fools and Horses.