For years, the Supreme Gangsters had an outstanding war with the Black Disciples Nation, led by David Barksdale.

[18] The gang had expanded through the North and West Sides of Chicago, as well as Indianapolis, Minneapolis, Kansas City, Detroit, Milwaukee, Cincinnati, Birmingham, Hattiesburg, and co-founder Hoover's birthplace of Jackson.

Other members who felt disrespected by Hoover's declining orders decided to get his attention again by instigating gang-related shootings toward the new GD's.

[23] On July 3, 2005, men claiming to be members of the Gangster Disciples street gang killed Sergeant Juwan Johnson of the U.S. Army in the small town of Hohenecken (part of the city of Kaiserslautern) near Ramstein, Germany.

Prosecutors accused U.S. Air Force Senior Airman Rico Williams of being the first one to start attacking Johnson in a six-minute beating that he had to endure to join the gang.

Some of the charges against the servicemen were: Williams, second-degree murder and witness tampering; Air Force Staff Sergeant Jerome Jones, conspiracy to commit assault, gang participation, and other charges; Airman Nicholas Sims and Army Sergeant Rodney Howell; involuntary manslaughter; Private Terrance Norman, voluntary manslaughter.

[29] Allegations were originally made that the Gangster Disciples were responsible for the event which came to be known as "The Lester Street Massacre" and was featured in two separate episodes of The First 48 on A&E.

[29] On July 21, 2020, a car pulled up to a funeral home in Chicago's Englewood area, and two gunmen infiltrated the property, opening fire.

The funeral was for a victim killed a week prior, and was allegedly involving a dispute between two Gangster Disciples factions.

In addition, the Gangster Disciples trafficked in large amounts of heroin, cocaine, methamphetamine, illegal prescription drugs, and marijuana.

Other acts of violence alleged as part of the conspiracy include a nightclub stabbing in East St. Louis, Illinois, a nonfatal shooting in Cape Girardeau and multiple unsuccessful murder plots.

[33] On August 22, 1995, after a 17-year undercover joint investigation by the Illinois Department of Corrections, Federal Bureau of Investigation, Bureau of Alcohol, Tobacco, Firearms and Explosives, Hoover was arrested for conspiracy, extortion, money laundering, drug-related offenses, and continuing to engage in a criminal enterprise.