Gangsters 2: Vendetta is a real-time strategy video game, developed by Hothouse Creations, published by Eidos Interactive, and released for Microsoft Windows in June 2001.

In Gangsters 2, each member of the player's gang can have up to four hoods to assist them, improving their firepower and providing a shield from attacks, and have access to a specialised skill  – bombing, kidnapping, assassination, charmer, bank robbery and getaway driver  – which can be used to help in a variety of ways: a charmer can use his influence to reduce the threat of police officers, while a bomber can use explosives either on cars to kill rival gangster or to bomb rival businesses.

Gangsters can be equipped with a variety of weapons, including revolvers, shotguns, dual pistols, submachine guns, and rifles, and use a selection of vehicles to travel around a map more quickly and perform drive-by shootings, and can rest in secured businesses to recover any health lost.

In the single-player mode, the player assumes the role of a gangster, and must complete objectives in each mission of the game's campaign within a set time limit, ranging from securing assets to eliminating rivals.

He eventually expands out of Buffalo Falls to weaken his target's racket operations, until he finally corners and kill Langsten, taking full control of his territory in the county.

This prompts Joey to build his empire carefully as he moves towards New Temperance, Constantine's stronghold, combatting threats from hitmen, corrupt police chiefs and church priests, and even trouble from demobbed army soldiers.