Between 1895—1896 a new wing of the station was built, which included a "Royal Hall", in anticipation of the visit of Emperor Franz Joseph of Austria-Hungary.

The station and its surroundings were heavily bombed by the Allies in April 1944 during a campaign aimed at Axis supply lines.

During the 2022 Russian invasion of Ukraine, from 27 February 2022 onwards, the station served as a coordination point for Ukrainian refugees.

As of 2009, Gara de Nord served about 200 routes, including domestic routes operated by Căile Ferate Române, Regiotrans and Transferoviar Călători, as well international trains to Austria (Vienna), Belarus (Minsk), Bulgaria (Sofia, Varna and Burgas), Hungary (Budapest), Republic of Moldova (Chișinău), Russia (Moscow and Saratov), Turkey (Istanbul), and Ukraine (Kyiv, Dnipro and Chernivtsi).

The station is additionally connected by CFR and TFC trains to Henri Coandă International Airport.