On 21 November 1918, the city council of Limoges and CF du PO signed an agreement regarding the construction of a new station.

The Germans also used an underground roadway as a passive defense shelter, located under the tracks, which previously linked the Ambazac road to Locarno Avenue, now partly walled.

On the night of 23–24 June 1944, thanks to information from the Resistance, the Allies bombarded the Puy-Imbert marshalling yard in Limoges, preventing the movement of trains for more than a week.

Following the failure of a splint, a metal part used to connect two consecutive rails, several cars from a passenger train between Paris-Austerlitz and Limoges-Bénédictins derailed, resulting in the death of seven people.

On May 20, 2008, the Limoges station was used for the filming of an advertising clip for the perfume Chanel No 5, "Un train de nuit", directed by Jean-Pierre Jeunet and featuring actress Audrey Tautou.

At the end, broadcast in 2009, the station appears at the very beginning of the clip, Audrey Tautou running on the forecourt and causing some pigeons to fly up.