Since 2004, he has been CEO of Carnival Films, the British studio which has produced television series such as Poirot, Traffik, Jeeves and Wooster, Hotel Babylon, Whitechapel and Stan Lee's Lucky Man.

In 2008, Neame sold the company to NBCUniversal[4] as part of its new international TV studios, producing shows such as The Philanthropist for NBC and the historical drama series Downton Abbey.

[7] In August 2015, Neame accepted a BAFTA Special Award in recognition of Downton Abbey's global success, alongside Julian Fellowes and members of the cast.

He has collaborated with Sir David Hare on his Worricker trilogy, and produced the BAFTA award-winning series The Lost Honour of Christopher Jefferies and Any Human Heart.

[17] When Neame discovered that a portrait of his great-grandmother Ivy Close – which had been painted by Sir Arthur Hacker after she won the Daily Mirror's contest to find the World's Most Beautiful Woman, exhibited at the Royal Academy in London, and used to fill the newspaper's front page on 4 May 1908 – was in the collection of the Ferens Art Gallery in Hull but not on display because it required restoration, he paid for the necessary work.

[18] Neame is a Life Patron of The Landmark Trust and through his charitable foundation supports causes including Together for Short Lives, music and drama scholarships, youth organisations, conservation and the arts and veterans.