New cast members include Billy Connolly, Ian Abercrombie, Roger Rees, Lucy Davis and Oliver Muirhead in live-action roles and Tim Curry, Bob Hoskins, Rhys Ifans, Vinnie Jones, Joe Pasquale, Richard E. Grant, and Jane Leeves as the voices of the film's new animal characters.

The story is loosely inspired by Mark Twain's novel The Prince and the Pauper, while its title is a parody of Charles Dickens' A Tale of Two Cities.

Two years after the events of the first film, Jon Arbuckle plans to propose to his girlfriend, veterinarian Elizabeth "Liz" Wilson, who is going on a business trip to London.

In the grand estate, Garfield receives a great deal of special treatment from both Smithee and Prince's farm animal followers led by his loyal bulldog majordomo, Winston, who convinces his fellow animals to tolerate and protect Garfield in order to prevent Dargis from getting his hands on the estate, which he plans to turn into a resort by demolishing the area and slaughtering them all.

It also includes a music video, trailers, featurettes, a new Garfield comic strip by creator Jim Davis, and an extended cut with eight minutes of footage not seen in theaters.

The site's critical consensus reads, "Strictly for (very) little kids, A Tale of Two Kitties features skilled voice actors but a plot that holds little interest.

Superior in every way to its underwhelming predecessor, Garfield: A Tail of Two Kitties is a genuinely clever kidpic that should delight moppets, please parents – and maybe tickle a few tweens.

"[11] Janice Page of The Boston Globe gave the film one and a half stars out of four, saying "You'll only be attracted to Garfield: A Tail of Two Kitties if you're very young, you're very easily entertained, or you just can't get enough of Jim Davis's lasagna-scarfing cartoon cat.

"[13] Elizabeth Weitzman of New York Daily News gave the film one and a half stars out of four, saying "Connolly, bless him, throws himself heartily into the task of acting opposite a computer-generated cat given to bad puns and flatulence.

"[14] Peter Hartlaub of the San Francisco Chronicle gave the film one out of four stars, saying "The best thing that can be said about Garfield: A Tail of Two Kitties is that the movie isn't quite as bad as its name.

"[16] Claudia Puig of USA Today gave the film one and a half stars out of four, saying "It comes off like a coughed-up furball: a wan rehash with too many elements of the hard-to-swallow 2004 original.