Headquartered in Boulder, Colorado, United States, the team maintains an equipment and training facility in Girona, Catalonia, Spain.

[a] Between 2008 and 2021, the team won 36 Grand Tour stages and 37 national road race and time trial championships.

5280 and TIAA–CREF continued to sponsor Garmin's youth riders in subsequent years, followed by the restaurant chain Chipotle Mexican Grill.

The name was changed again in June 2008 after the navigation system manufacturer Garmin was announced as the title sponsor, a week prior to the 2008 Tour de France.

Their first major Tour was the 2008 Giro d'Italia, where they won the Team Time Trial and Christian Vande Velde wore the pink jersey for one stage.

In the 2009 Vuelta a España the sprinter Tyler Farrar, the time trial specialist David Millar and the Canadian Ryder Hesjedal took stage wins for the team.

On August 28, 2010, Garmin-Transitions announced it was switching working agreements from Felt Bicycles to Cervélo bikes, and that it would change its name to Garmin–Cervélo for the 2011 season.

[11] The 2015 season did not match the team's expectations, with only one World Tour win, courtesy of Davide Formolo at the Giro d'Italia.

Notable results include: the 2009 Vattenfall Cyclassics and the 2010 Vattenfall Cyclassics with American Tyler Farrar, the 2010 Tour de Pologne, the 2013 Volta a Catalunya, the 2013 Liège–Bastogne–Liège, and the 2014 Giro di Lombardia with Irishman Dan Martin, the 2011 Tour Down Under with Australian Cameron Meyer, the 2011 Paris–Roubaix with Belgian Johan Vansummeren, the 2012 Giro d'Italia with Canadian Ryder Hesjedal, the 2014 Critérium du Dauphiné with American Andrew Talansky, the 2019 Tour of Flanders with Italian Alberto Bettiol, the 2019 Bretagne Classic Ouest–France with Belgian Sep Vanmarcke, the 2020 Critérium du Dauphiné with Colombian Daniel Martínez, and the 2021 Clásica de San Sebastián with American Neilson Powless.

In 2010, Briton David Millar won the silver medal at the UCI Road World Time Trial Championships.

When the team entered the Professional Continental ranks they began in the Agency for Cycling Ethics[15] program to eliminate doping.

On 26 August 2017, during the Vuelta a España, Vaughters announced that a sponsor had backed out of a commitment to provide the team with funding for the following season, and that riders under contract for 2018 were free to seek employment elsewhere.

An employee of EF Education First contacted Vaughters after learning of Slipstream Sports' plight and alerted higherups at the company about the issue.