Garretson is a city in Minnehaha County, South Dakota, United States.

There were 476 housing units at an average density of 328.3 per square mile (126.8/km2).

26.9% of all households were made up of individuals, and 12.9% had someone living alone who was 65 years of age or older.

As of the census of 2000, there were 1,165 people, 427 households, and 313 families living in the city.

There were 458 housing units at an average density of 309.4 per square mile (119.5/km2).

24.4% of all households were made up of individuals, and 13.1% had someone living alone who was 65 years of age or older.

Garretson is home to Devil's Gulch, the site where Jesse James allegedly escaped a posse after robbing the First National Bank in Northfield, Minnesota, and Split rock park, the site of the cities bathhouse from the founding.