[6] On 20 July 2009, he joined Boca Juniors on an initial loan for US$300,000 with the option to buy for $2.5 million, with Damián Díaz being sent in the opposite direction.

It is a very important club, and one which has players which I admire a lot, Juan Román Riquelme, Martín Palermo and Sebastián Battaglia.

[9] Medel joined Sevilla for €3 million on 28 January 2011, on a 4+1⁄2-year contract, on the same day as the club also signed Ivan Rakitić for their central midfield.

[11] He helped Sevilla to a 1–1 draw against FC Barcelona at home on 12 March, clearing the ball off the line twice, the second on an attempt by Lionel Messi.

[12] On 11 August 2013, Cardiff City confirmed that they had signed Medel from Sevilla for a club record £11 million fee on a four-year deal.

[16] After Cardiff's relegation, Medel joined Italian club Inter Milan for a reported £10 million fee on 9 August 2014.

[19] Medel made his Serie A debut for Inter on 31 August as they began the season with a goalless draw at Torino, playing the full 90 minutes.

[20] On 31 October 2015, Medel scored his first goal for Inter to give the Nerazzurri a 1–0 victory over Scudetto rivals Roma at the Stadio Giuseppe Meazza.

[21] On 23 October 2016, in the 2–1 away defeat at Atalanta, Medel hit Jasmin Kurtić in the face with his left arm, an incident that was not spotted by the referee.

[23] On 20 November 2016, in the Derby della Madonnina against cross-town rivals A.C. Milan, Medel played as centre-back for 37 minutes before replaced by Jeison Murillo due to a knee injury.

[39] He made his competitive debut for Chile in the 2010 FIFA World Cup qualification match against Bolivia in a 2–0 victory at the Estadio Hernando Siles in La Paz, scoring both goals, the first being a bicycle kick.

[42] Medel played as a starter alongside Gonzalo Jara in the center of defense, for Chile who beat Australia 3–1 in Cuiabá to get their first three points of the World Cup campaign.

[47][48][49] At the 2015 Copa América, held in Chile, Medel scored during a 5–0 win against Bolivia which ensured that La Roja would progress to the knockout stage as Group A winners.

[51] In the final against Argentina, Medel played as a starter and helped the team to win the trophy on penalty kicks, after the regular time ended in a goalless draw.

[4][61] Due to his work-rate, physicality, tenacity, tactical intelligence, and his aggressive, hard-tackling style of play, as well as his leadership on the pitch, he is nicknamed Pitbull.