He began his professional career abroad with teams in Turkey, Spain and Italy before signing with the San Antonio Spurs in 2010.

For his senior year, he enrolled at Calvert Hall College High School, to play in the Baltimore Catholic League.

[1] Before the 2004–05 season, Neal was dismissed from the team due to a rape allegation by a University of New Haven women's basketball player who was working at La Salle camp.

[1] He initially joined Towson with no athletic aspirations, but was given a walk-on spot on their basketball team in 2005–06 conditional on the result of his rape case.

When playing for Pınar Karşıyaka, Neal led the Turkish Basketball Super League in scoring, averaging 23.6 points per game.

[10] On April 27, 2011, during game 5 of the first round of the NBA playoffs and the Spurs trailing the Memphis Grizzlies 97–94 and the series 3–1, Neal hit a three-pointer with 1.7 seconds left in the fourth quarter.

[17] On June 11, 2013, in Game 3 of the 2013 NBA Finals, Neal scored a career playoff-high of 24 points on 9 of 17 from the field, including 6 of 10 three-pointers to help lead the Spurs to a blowout 113–77 victory over the Miami Heat.

[20] On February 20, 2014, Neal and Luke Ridnour were traded to the Charlotte Bobcats in exchange for Jeff Adrien and Ramon Sessions.

[22] On February 10, 2015, Neal was traded, along with Miami's 2019 second-round draft pick, to the Minnesota Timberwolves in exchange for Mo Williams, Troy Daniels and cash considerations.

[26] Ten days later, he made his debut with Westchester in a 118–114 loss to the Long Island Nets, recording four points, one rebound and one steal in 13 minutes off the bench.

[28] Four days later, he made his debut for the Legends in a 148–122 loss to the Sioux Falls Skyforce, recording 18 points, four rebounds, three assists and one steal in 26 minutes off the bench.

[37][38] In 2021, Neal was named as the head coach of the varsity basketball team at his alma mater, Calvert Hall College High School.