In addition to its own musical score by Greg O'Connor and title theme by Bottlefly, the series has had a number of licensed songs that can be heard throughout most of the episodes.

[3] Gary and Mike is about two best friends traveling across the United States on a road trip, accomplishing nothing of importance, and unwittingly destroying hopes, dreams, and personal property.

Gary is a fairly normal, albeit high-strung, uptight, good hearted loser while Mike is the fun-loving, laid back, "best friend from hell" with a sex addiction.

[citation needed] The story begins in St. Louis, Missouri, where Gary Newton bids farewell to his nursing home patients as he prepares to embark on a journey following the Lewis and Clark trail.

Gary sets off on his trip in his SUV, with Mike unexpectedly joining him to escape Julie's angry father, Officer Dick.

Despite the chaotic events, Gary reflects on the trip with a mix of frustration and camaraderie towards Mike, who remains determined to keep exploring rather than face his father's wrath.

In hilarious sit-com fashion, he fails every time to notice that she has a growth that covers half her face, but Mike sure does...until Gary goes to her house to meet her.

Officer Dick also manages to find the duo's car after tracking them for so long and seeks to exact his revenge on Mike, under the cover as a hippie himself.

WWF wrestler Chyna makes a guest appearance and falls in love with Gary's new "friend" at the end of the episode.

Officer Dick catches up with Ben, whom he believes is Mike under an assumed identity, and shoots out the tires of his SUV which he won at the end of the Road Rage program.

Gary seems to be helping a great deal, but without knowing it is causing more trouble than the campaign can stand, meanwhile Mike finds himself falling for a much, much older woman who is a Supreme Court Justice.

Meanwhile Mike is counting cards in the casino owned by the same honked-off mobsters who gave them their hotel room, as his source of income.

Gary and Mike are in The Big Apple, New York, and their car gets stolen; so they decide to disguise themselves as Jews and go to a bar mitzvah.

After Dick lands into a gay bar, both of them run over a speed-bump, causing Mike to spill his Slurpee on the Marine Corps flag Gary bought for his dad, as well as his shirt.