Gash-Setit is a 709 km2 (274 sq mi) designated national wildlife reserve and historical area of western Eritrea where its considered to be the northern most point of Africa for elephant habitat.

It is the historical area of the Kunama people and a very fertile region extending to the Sudan border.

[2] Crops such as sorghum, millet, legumes, cotton and sesame are produced in the area.

[3] Citrus fruits and bananas were also produced in the Gash-Setit but many of the plantations were destroyed during the Eritrean War of Independence in the 1960s or by the Ethiopian army during the 2000 conflict.

Formerly part of Ethiopia, in 1992 according to the United Nations Observer Mission to Verify the Referendum in Eritrea a total of 73,236 people out of 73,506 surveyed in the area had voted for Eritrea to become an independent nation[4] The park was under the administration of Germano Nati.