The Gauliga Mittelrhein was the highest football league in the central and southern part of the Prussian Rhine Province from 1933 to 1945.

Due to the outbreak of World War II in 1939, the league was split into two regional groups, a northern division of seven and a southern of six clubs.

There is no record of play in the 1944-45 season as war overtook the region, including the conquest of Aachen by the allied forces.

The Oberliga Südwest was introduced as the highest football league in the French occupation zone in 1945, replacing the Gauliga.

In the British zone, which the former Gau Köln-Aachen was part of, top-level football did not resume straight away, unlike in Southern Germany, and only in 1947 was a new, highest league introduced, the Oberliga West, which covered all of the new state of North Rhine-Westphalia.

The most successful of those was the FV Stadt Düdelingen, who reached the German championship finals round, losing to the FC Schalke 04 0-2 in 1942.