After signing with Atlantic Records and Arthouse Entertainment, she released her hit single "ABCDEFU" in 2021, which charted worldwide, including reaching number one in the United Kingdom,[5] Ireland,[6] and on the Billboard Global 200 and earned her a Grammy Award nomination for Song of the Year.

[7] She started singing at the age of seven and eventually moved to Nashville, Tennessee, to pursue a musical career.

[8] She reports that she is dyslexic[9] and has chromesthesia, sound-to-color synesthesia in which sound involuntarily evokes an experience of color.

[14] On March 18, 2022, Gayle released a six-song extended play (EP) titled A Study of the Human Experience Volume One via Atlantic and Arthouse.

[15][16][17] On March 19, 2022, Gayle was a fill-in host for the CHR version of Ryan Seacrest's American Top 40, where her song "ABCDEFU" spent its first week at number one.

[24] On April 14, 2023, Lauren Spencer-Smith's "Fantasy", a collaboration with Gayle and Em Beihold, was released as the sixth single from Spencer's album, Mirror (2023).