Comensoli left her family in 1862 and joined the convent of the Sisters of Charity, founded by St. Bartolomea Capitanio in Lovere, Bergamo.

[1] After her recovery, she left her village due to the financial situation of her family and entered into domestic service, first with G. B. Rota, parish priest of Chiari, who a few years later was to become the Bishop of Lodi.

Without neglecting her duties as a domestic servant, Caterina decided to educate the children of San Gervasio, Bergamo, guiding them towards an honest life of Christian and social virtues.

Freed from family responsibilities after her parents’ death, the young woman sought a way to live a religious life.

Comensoli opened her heart to the Bishop of Bergamo, Pietro Luigi Speranza, who was, at that time, in Bienno as a guest of the Fé-Vitali's.

In 1880, while in Rome with the Fé-Vitali's, Comensoli succeeded in speaking with Pope Leo XIII about her plans to establish a religious institute devoted to the adoration of the Eucharist.

On 1st November 1894 she opened a house of nuns in Castelnuovo Bocca d'Adda and in the same years in Lavagna, in the province of Lodi.