Musicians who played in his groups, apart from Stitt, included Donald Byrd, Jackie McLean, John Coltrane, Kenny Burrell, Mal Waldron, Art Farmer, and Duke Jordan.

After his release from prison in 1969, having served a seven-year sentence at Joliet penitentiary, he signed the largest contract ever offered at that time by Prestige's Bob Weinstock.

Ammons, together with Dexter Gordon and Sonny Stitt, helped integrate their developments with the emerging "vernacular" of the bebop movement, and the chromaticism and rhythmic variety of Charlie Parker is evident in his playing.

While adept at the technical aspects of bebop, in particular its love of harmonic substitutions, Ammons stayed in touch with the commercial blues and R&B of his day.

With a thicker, warmer tone than Stitt or Gordon, Ammons could at will exploit a vast range of textures on the instrument, vocalizing it in ways that anticipated later artists such as Stanley Turrentine, Houston Person, and even Archie Shepp.