The Advanced Cockpit GCS has a wrap-around visual display and multi-dimensional moving map to increase situational awareness and reduce pilot workload.

The Advanced Cockpit GCS has flown an MQ-1 Predator and is planning to fly an MQ-9 Reaper as part of an Air Force initiative to enable interoperability with all USAF Remote Piloted Aircraft (RPA).

[15] On November 28, 2023, an Avenger test deployed the Advanced Air-Launched Effects (A2LE) small uncrewed aerial system (sUAS) from its internal weapons bay over Dugway Proving Ground, Utah.

Due to the longer distances from potential targets, General Atomics has pitched the Avenger to the Central Intelligence Agency as a better drone for the mission.

[20] General Atomics has offered the Predator C Avenger to Canada as a contender for its Joint Unmanned Surveillance and Target Acquisition System (JUSTAS) armed UAV project.

The RCAF has requested that the drones be armed, therefore making the General Atomics Avenger the only suitable contender, as the Northrop Grumman RQ-4 Global Hawk is unarmed.

Canada will begin to refine the preliminary requirements with General Atomics and L3 Technologies until a formal request for proposals and contract is awarded.

[23] On 22 September 2015, the U.S. stated they backed India's membership in the Missile Technology Control Regime, which would enable them to buy armed drones.

[24] As of 17 August 2017, General Atomics Aeronautical Systems (GA-ASI) is in the early stages of negotiating the potential sale of as many as 100 Predator C Avenger remotely piloted aircraft to an unidentified international customer.

The renewed international interest is believed to be led by India, which has requested access to the capability as a potential follow-on to the planned acquisition of as many as 20 GA-ASI MQ-9 UAVs, 10 each for its Army and Navy[25] and wants to acquire 100 Avenger drones for its Air Force at the cost of $8 billion.

As requirements for the UCLASS program were altered from a high-end strike aircraft to an ISR machine operating in permissive environments, the Sea Avenger was modified accordingly.

[29] If Navy requirements favored a UAV optimized for permissive ISR over broadband stealth, the Sea Avenger would better meet them, as it was originally pitched as having a reduced signature to be "stealthier" than other aircraft.

[29] In October 2017, General Atomics released images of its submission for the Navy's MQ-25 Stingray, an unmanned aerial tanker that formed out of the UCLASS effort.

The Avenger ER uses a modified fuselage design (completed in 2012) extended by four feet (to 13.4 m (44 ft)) to accommodate larger payloads and more fuel.

Earlier in 2016, the U.S. Federal Aviation Administration granted GA-ASI an experimental certificate that allows it to fly the Avenger in the National Airspace System.