The agency is organized in these major divisions: The Upper Room is a global ministry that supports the spiritual formation of Christians.

From its beginnings as a daily devotional guide, Upper Room Ministries has grown to include publications, programs, prayer support and other resources to help people of all ages and denominations.

Upper Room Ministries also publishes books and magazines for people of all ages and provides various programs and events.

Leadership Ministries provides resources to both the laity and clergy leaders of The United Methodist Church who work in local congregations, districts and annual (regional) conferences.

Grants, scholarships and consultations are available to help local churches develop projects and programs that support young people.