The General López Department (in Spanish, Departamento General López) is an administrative subdivision (departamento) of the province of Santa Fe, Argentina.

Its head town is Melincué (population 2,200), and its largest city is Venado Tuerto (population 70,000).

It is bordered by the Caseros Department in the north, and by the Constitución Department in the north-east; the rest of its borders coincide with interprovincial limits (with Córdoba in the west and with Buenos Aires in the south and east).

The towns and cities in this department are (in alphabetical order): Aarón Castellanos, Amenábar, Cafferata, Cañada del Ucle, Carmen, Carreras, Chapuy, Chovet, Christophersen, Diego de Alvear, Elortondo, Firmat, Hughes, La Chispa, Labordeboy, Lazzarino, Maggiolo, María Teresa, Melincué, Miguel Torres, Murphy, Rufino, San Eduardo, San Francisco de Santa Fe, San Gregorio, Sancti Spiritu, Santa Isabel, Teodelina, Venado Tuerto, Villa Cañás, Wheelwright.

This article about a place in Santa Fe Province, Argentina is a stub.